Associations among blood heavy metals, neurofilament light chains and cognition function in US adults: NHANES 2013–2014

This study is the first to utilize sNfL data to establish a link between heavy metals exposure and cognitive function. The finding highlight the the positive correlation between Pb or Cd and sNfL, the negative correlation between Se and sNfL. The impact of Cd exposure on cognitive function in individuals older than 60 was partially explained by sNfL. Further investigations are required to validate these findings, considering the constraints of the NHANES study.

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Publication Details

Journal
Ecotoxicology and Environmental Safety
Published
2025-05-23
DOI
https://doi.org/10.1016/j.ecoenv.2025.118369
Citations
7
Primary Topic
Heavy Metal Exposure and Toxicity
Type
article
Field-Weighted Citation Impact
8.40
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article

Associations among blood heavy metals, neurofilament light chains and cognition function in US adults: NHANES 2013–2014

Xiaobo Zhu, Z.-Y. Zhang, Y Zhou, Hongtao Zeng et al.
7 citations
Ecotoxicology and Environmental Safety
Heavy Metal Exposure and Toxicity
8.40
article

Associations among blood heavy metals, neurofilament light chains and cognition function in US adults: NHANES 2013–2014

Xiaobo Zhu, Z.-Y. Zhang, Y Zhou, Hongtao Zeng, Yuanxin Man, Cheng Qiu, Yunguang Wang, Xuefeng Guo, Shanyong Tan
article en
7 citations

Abstract

This study is the first to utilize sNfL data to establish a link between heavy metals exposure and cognitive function. The finding highlight the the positive correlation between Pb or Cd and sNfL, the negative correlation between Se and sNfL. The impact of Cd exposure on cognitive function in individuals older than 60 was partially explained by sNfL. Further investigations are required to validate these findings, considering the constraints of the NHANES study.

Ecotoxicology and Environmental SafetyVol. 299
Sun Yat-sen University (CN), Guangxi Medical University (CN), Guilin Medical University (CN), The First Affiliated Hospital, Sun Yat-sen University (CN)
Openalex Percentile: Top 2%
Heavy Metal Exposure and Toxicity
8.40
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