The impact of perilesional heatsink structures on ablation volumes and symmetry in laser interstitial thermal therapy for the treatment of primary central nervous system tumors
This study shows that proximity to heatsinks, especially within a threshold distance of 13.0 mm from the laser catheter, significantly predicts ablation asymmetry and volume in the setting of primary CNS tumors. Vasculature and CSF spaces demonstrate the strongest heatsink effects. Neurosurgeons should consider heatsink effects in pre- and intraoperative planning to optimize LITT outcomes and preserve normal brain tissue.
Authors
- Adham M. Khalafallah (ORCID: https://orcid.org/0000-0002-3249-9657)
- Adam Shapira Levy (ORCID: https://orcid.org/0000-0002-7582-0877)
- Cameron Rivera
- Shovan Bhatia (ORCID: https://orcid.org/0000-0001-8090-7208)
- Chandler Berke (ORCID: https://orcid.org/0000-0002-9787-8164)
- Victor M. Lu (ORCID: https://orcid.org/0000-0002-9470-5890)
- Ashish H. Shah (ORCID: https://orcid.org/0000-0002-0183-1274)
- Ricardo J. Komotar (ORCID: https://orcid.org/0000-0002-7626-8869)
- Michael E. Ivan (ORCID: https://orcid.org/0000-0002-4798-4989)
- Chase DeLong (ORCID: https://orcid.org/0009-0007-3881-288X)
- Eric Singh (ORCID: https://orcid.org/0009-0000-6482-244X)
- David Levi
- Kate Stillman
Institutions
- University of Miami (US)
- University of Pittsburgh (US)
- Neurological Surgery (US)
Publication Details
- Journal
- Journal of neurosurgery
- Published
- 2025-05-23
- DOI
- https://doi.org/10.3171/2025.1.jns241377
- Primary Topic
- Optical Coherence Tomography Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00