Training-induced plasma miR-29a-3p is secreted by skeletal muscle and contributes to metabolic adaptations to resistance exercise in mice
Our study suggests that miR-29a-3p is a training-induced molecular mediator in the response and adaptation to resistance training, possibly due to its regulatory role in energy metabolism in skeletal muscle in response to exercise.
Authors
- Juleen Rae Zierath (ORCID: https://orcid.org/0000-0001-6891-7497)
- Sergio Díez‐Robles
- Benjamín Fernández‐Garcia (ORCID: https://orcid.org/0000-0002-2391-680X)
- Almudena Coto-Vilcapoma (ORCID: https://orcid.org/0000-0002-9856-6939)
- Pablo M. García-Rovés (ORCID: https://orcid.org/0000-0002-8371-2067)
- Pau Gama-Pérez (ORCID: https://orcid.org/0000-0003-4342-0286)
- David Roiz‐Valle (ORCID: https://orcid.org/0000-0001-9131-6155)
- Manuel Fernández‐Sanjurjo (ORCID: https://orcid.org/0000-0003-4687-3379)
- Paola Pinto-Hernández (ORCID: https://orcid.org/0000-0003-4155-2015)
- Anna Krook (ORCID: https://orcid.org/0000-0002-0891-0258)
- Eduardo Iglesias‐Gutiérrez (ORCID: https://orcid.org/0000-0002-3063-1562)
- Xurde M. Caravia (ORCID: https://orcid.org/0000-0002-1173-7003)
- Cristina Tomás‐Zapico (ORCID: https://orcid.org/0000-0001-7823-0410)
- Daan Paget (ORCID: https://orcid.org/0000-0002-1628-4680)
- Carlos López-Otı́n (ORCID: https://orcid.org/0000-0001-6964-1904)
- Juan Castilla‐Silgado (ORCID: https://orcid.org/0000-0002-6266-8247)
- David Fernandez-Vivero
Institutions
- Universidad de Oviedo (ES)
- Gobierno del Principado de Asturias (ES)
- Karolinska Institutet (SE)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Ajuntament de L’Hospitalet (ES)
- Department of Physiological Sciences (RU)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1016/j.molmet.2025.102173
- Citations
- 3
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Ministerio de Economía y Competitividad
- Fundación para el Fomento en Asturias de la Investigación Científica Aplicada y la Tecnología
- Fundación Tatiana Pérez de Guzmán el Bueno
- Instituto de Salud Carlos III