Investigating interassay variability between direct oral anticoagulant calibrated anti–factor Xa assays: a substudy of the perioperative anticoagulation use for surgery evaluation (PAUSE) trial
Anti-FXa levels determined by 3 common instrument-reagent combinations show moderate-to-very strong correlations with each other. Although there are statistically significant differences between median anti-FXa levels these differences are not clinically significant, and result in discrepant classification across the 30 ng/mL threshold in only 7.8% of samples.
Authors
- Karen A. Moffat (ORCID: https://orcid.org/0000-0002-6431-5525)
- Alex C. Spyropoulos (ORCID: https://orcid.org/0000-0002-3175-461X)
- Ross Baker (ORCID: https://orcid.org/0000-0002-2728-6788)
- Melanie St John
- Rita Selby (ORCID: https://orcid.org/0000-0003-3051-4427)
- James D. Douketis (ORCID: https://orcid.org/0000-0001-5288-0394)
- Sam Schulman (ORCID: https://orcid.org/0000-0002-8512-9043)
Institutions
- University of Toronto (CA)
- Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US)
- McMaster University (CA)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.rpth.2025.102899
- Citations
- 2
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.78