CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovial tissue
CD4+ TRM17 cells are the predominant source of IL-17A in SpA synovial tissue. TCR stimulation is essential for the secretion of IL-17A by CD4+TRM17-like cells. The epigenetic regulator bromodomain-containing protein 1 (BRD1) contributes to the generation of CD4+TRM17. Depleting CD4+TRM17 cells in SpA is thus a therapeutic strategy with potential to induce long-term remission.
Authors
- Dajiang Du (ORCID: https://orcid.org/0000-0002-4204-9721)
- Jason D. Turner (ORCID: https://orcid.org/0000-0002-5423-5302)
- Hui Shi (ORCID: https://orcid.org/0000-0003-1524-4553)
- Alex Adams (ORCID: https://orcid.org/0000-0001-9364-8540)
- Brian D. Marsden (ORCID: https://orcid.org/0000-0002-1937-4091)
- Hai Fang (ORCID: https://orcid.org/0000-0003-3961-8572)
- Fiona E. McCann (ORCID: https://orcid.org/0000-0001-8151-8781)
- Lihua Duan (ORCID: https://orcid.org/0000-0002-1631-4675)
- Jiewei Chen (ORCID: https://orcid.org/0000-0002-5399-725X)
- Ariane Hammitzsch (ORCID: https://orcid.org/0000-0003-2658-4764)
- Feng Liu (ORCID: https://orcid.org/0000-0001-5794-0405)
- Matthias Friedrich (ORCID: https://orcid.org/0000-0002-7551-4853)
- Calliope Athena Dendrou (ORCID: https://orcid.org/0000-0003-1179-4021)
- Christopher B. Mahony (ORCID: https://orcid.org/0000-0003-4487-2540)
- Paul Bowness (ORCID: https://orcid.org/0000-0003-4597-0484)
- Roopa Madhu (ORCID: https://orcid.org/0000-0001-6226-160X)
- Adam P. Cribbs (ORCID: https://orcid.org/0000-0001-5288-3077)
- Andrew D. Filer (ORCID: https://orcid.org/0000-0001-8164-6249)
- Tom C. Freeman (ORCID: https://orcid.org/0000-0001-5235-8483)
- Ilya Korsunsky (ORCID: https://orcid.org/0000-0003-4848-3948)
- Graham S. Ogg (ORCID: https://orcid.org/0000-0002-3097-045X)
- Liye Chen (ORCID: https://orcid.org/0000-0003-1503-6017)
- Warner Chen
- Terence Rooney
- Christopher Dominic Buckley (ORCID: https://orcid.org/0000-0001-6924-6402)
- Takuya Sekine (ORCID: https://orcid.org/0000-0001-7649-0593)
- Holm H. Uhlig (ORCID: https://orcid.org/0000-0002-6111-7355)
- Adam P. Croft (ORCID: https://orcid.org/0000-0002-9487-0511)
- Qiang Tong (ORCID: https://orcid.org/0000-0002-4692-9363)
- Kyla Dooley (ORCID: https://orcid.org/0000-0003-2914-3040)
- Steven Leonardo (ORCID: https://orcid.org/0000-0002-4656-8078)
- Devika Agarwal (ORCID: https://orcid.org/0000-0002-5203-307X)
- Jiaqi Li (ORCID: https://orcid.org/0009-0002-9681-8300)
- Yi‐Ling Chen (ORCID: https://orcid.org/0000-0003-3758-0638)
- Benjamin Kendrick
- Rachel Anscombe
Institutions
- Broad Institute (US)
- Centre for Human Genetics (GB)
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Queen Elizabeth Hospital Birmingham (GB)
- Ruijin Hospital (CN)
- Nuffield Orthopaedic Centre (GB)
- TUM Klinikum (DE)
- Karolinska Institutet (SE)
- University of Oxford (GB)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Jiangxi Provincial People's Hospital (CN)
- MRC Weatherall Institute of Molecular Medicine (GB)
- MRC Human Immunology Unit (GB)
- NIHR Surgical Reconstruction and Microbiology Research Centre (GB)
- Shanghai Sixth People's Hospital (CN)
- Oxford BioMedica (United Kingdom) (GB)
- Science Oxford (GB)
- Shanghai Institute of Hematology (CN)
- Janssen (United States) (US)
- NIHR Birmingham Biomedical Research Centre (GB)
- Technical University of Munich (DE)
- University of Birmingham (GB)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1016/j.ard.2025.04.018
- Citations
- 10
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 7.97
Funders
- National Institute for Health and Care Research
- Versus Arthritis