Total Synthesis and Antibacterial Activity of 5-Geranyloxy-7-hydroxycoumarin and Murrayacoumarin A
Coumarins are widely found in medicinal plants and exhibit diverse biological properties, including antibacterial activities. Herein, we report the total synthesis of 5-geranyloxy-7-hydroxycoumarin, 5-geranyloxy-7-methoxycoumarin, and Murrayacoumarin A. The asymmetric synthesis of (+)-Murrayacoumarin A was achieved via regioselective asymmetric dihydroxylation, allowing the determination of absolute configuration at the C7'-position. In addition, the antibacterial activities of the synthesized natural products and their derivatives were evaluated.
Authors
- Akiko Takaya (ORCID: https://orcid.org/0000-0003-1726-7150)
- Masami Ishibashi (ORCID: https://orcid.org/0000-0002-2839-1045)
- Tetsuhiro Nemoto (ORCID: https://orcid.org/0000-0001-8858-161X)
- Takahito Kuribara (ORCID: https://orcid.org/0009-0005-9556-9607)
- Honoka Yuba
- Hiroki Saito (ORCID: https://orcid.org/0000-0002-7355-3234)
Institutions
- Chiba University (JP)
- Chiba University Hospital (JP)
Publication Details
- Journal
- Chemical and Pharmaceutical Bulletin
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1248/cpb.c25-00127
- Citations
- 3
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article
- Field-Weighted Citation Impact
- 3.92
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science
- Core Research for Evolutional Science and Technology