Polygenic risk for schizophrenia predicting Big Five personality traits in individuals without non-affective psychosis
Individuals with high PRS for schizophrenia, who have not developed non-affective psychosis, may still develop mildly different personality traits, including higher Openness and lower Extraversion. These findings seem to be specific to PRSscz and are not observed for PRS<sub>DEP</sub>.
Authors
- Binisha H. Mishra (ORCID: https://orcid.org/0000-0002-5605-5196)
- Aino I. L. Saarinen (ORCID: https://orcid.org/0000-0003-4495-8360)
- Elina Sormunen (ORCID: https://orcid.org/0000-0002-8290-9052)
- Mika A. P. Kähönen (ORCID: https://orcid.org/0000-0002-4510-7341)
- Olli Tuomas Raitakari (ORCID: https://orcid.org/0000-0001-9365-3702)
- Jarmo A. Hietala (ORCID: https://orcid.org/0000-0002-3179-6780)
- Leo‐Pekka Lyytikäinen (ORCID: https://orcid.org/0000-0002-7200-5455)
- Terho J. Lehtimäki (ORCID: https://orcid.org/0000-0002-2555-4427)
- Veikka Lavonius (ORCID: https://orcid.org/0000-0001-9169-4359)
- Liisa Keltikangas-Järvinen
Institutions
- University of Helsinki (FI)
- Tampere University of Applied Sciences (FI)
- University of Turku (FI)
- Turku University Hospital (FI)
- Veikkaus (Finland) (FI)
- Tampere University Hospital (FI)
- Tampere University (FI)
- Fimlab (Finland) (FI)
Publication Details
- Journal
- Schizophrenia Research
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1016/j.schres.2025.05.017
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00