Ferroptosis Is Induced by Lysosomal Iron Activation in Cancer Cells

Major Finding: Iron activation within the lysosome triggers oxidative membrane lipid degradation and ferroptosis.Concept: Fentomycin-1 induces phospholipid oxidation and ferroptosis in cancer cells by activating lysosomal iron.Impact: Lysosomal iron is a druggable target in primary cancers, metastases, and drug-tolerant persister cells.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-046
Primary Topic
Ferroptosis and cancer prognosis
Type
article
Field-Weighted Citation Impact
0.00
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article

Ferroptosis Is Induced by Lysosomal Iron Activation in Cancer Cells

Cancer Discovery
Ferroptosis and cancer prognosis
article

Ferroptosis Is Induced by Lysosomal Iron Activation in Cancer Cells

article en

Abstract

Major Finding: Iron activation within the lysosome triggers oxidative membrane lipid degradation and ferroptosis.Concept: Fentomycin-1 induces phospholipid oxidation and ferroptosis in cancer cells by activating lysosomal iron.Impact: Lysosomal iron is a druggable target in primary cancers, metastases, and drug-tolerant persister cells.

Cancer Discovery
Good health and well-being
Openalex Percentile: Top 81%
Ferroptosis and cancer prognosis
DOISourceOpenAlex
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Ferroptosis Is Induced by Lysosomal Iron Activation in Cancer Cells · Cancer Discovery (2025) | TGRS Research Map | TGRS