Longitudinal neuropsychological evaluation allows diagnosis of MCI with less severe memory change
Longitudinal cognitive evaluation detects symptomatic Alzheimer's disease earlier than mental status exams. At the time of diagnosis, converters were less impaired compared to initially symptomatic patients. Converters' cognition declined more steeply than initially symptomatic patients. Sensitive cognitive tests are essential to capture early changes, given new disease-modifying therapies.
Authors
- Dixie J. Woolston
- Blake Langlais
- Cynthia M. Stonnington (ORCID: https://orcid.org/0000-0001-7843-4309)
- Bryan K. Woodruff (ORCID: https://orcid.org/0000-0002-4728-7294)
- Dona E.C. Locke (ORCID: https://orcid.org/0000-0002-1966-7716)
- Richard J. Caselli (ORCID: https://orcid.org/0000-0001-5784-2987)
- Leslie A. Baxter
Institutions
- Mayo Clinic in Arizona (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/alz.70317
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Wilson Foundation
- Ralph C. Wilson Foundation
- Arizona Alzheimer’s Consortium
- National Institutes of Health
- National Institute on Aging