Impact of GLP-1 receptor agonist-induced weight loss on 22 cancers in the next ten years using a Markov state-transition model – A UK weight and wellness cancer landscape analysis
Targeted weight control measures using GLP-1RAs could reduce new cancer cases. Based on our models, the potential risk of thyroid cancer is balanced by a reduction in other cancer types. This modelling study shows for the first time that implementing effective weight loss programmes could enhance the health of the population over the next decade through a reduction in cancer cases.
Authors
- David James Pinato (ORCID: https://orcid.org/0000-0002-3529-0103)
- Chris D. Turnbull (ORCID: https://orcid.org/0000-0001-8942-5424)
- Jiawen Dong (ORCID: https://orcid.org/0000-0002-7204-9431)
- Lennard Y. W. Lee (ORCID: https://orcid.org/0000-0002-8993-8438)
- Vinton W.T. Cheng (ORCID: https://orcid.org/0000-0003-4159-8697)
- Michaël Tilby (ORCID: https://orcid.org/0000-0003-1663-4860)
- Tim Robinson (ORCID: https://orcid.org/0000-0003-0933-646X)
- Thomas Starkey (ORCID: https://orcid.org/0000-0002-6692-9563)
- James J. Clark (ORCID: https://orcid.org/0000-0002-4512-6171)
Institutions
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- University Hospitals Birmingham NHS Foundation Trust (GB)
- University of Liverpool (GB)
- Imperial College Healthcare NHS Trust (GB)
- Churchill Hospital (GB)
- Hammersmith Hospital (GB)
- University Hospitals Coventry and Warwickshire NHS Trust (GB)
- University of Bristol (GB)
- University of Oxford (GB)
- Oxford Centre for Diabetes, Endocrinology and Metabolism (GB)
- Oxford BioMedica (United Kingdom) (GB)
- Oxford University Hospitals NHS Trust (GB)
- Bristol Robotics Laboratory (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- Cancer Epidemiology
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1016/j.canep.2025.102837
- Citations
- 3
- Primary Topic
- Cancer Risks and Factors
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- University of Oxford