Evaluation of broad-spectrum protection by novel mRNA vaccines against SARS-CoV-2 variants (Delta, Omicron-BA.5, XBB-EG.5) in the golden hamster model
These mRNA vaccines demonstrated broad protective efficacy against multiple SARS-CoV-2 variants. They elicited immune responses, reduced viral RNA loads, and mitigated inflammatory and pathological damage, highlighting their potential in combating rapidly evolving SARS-CoV-2 variants.
Authors
- Jun-Hong Xing
- Mingyao Tian (ORCID: https://orcid.org/0000-0003-0360-3635)
- Xinyu Zhuang (ORCID: https://orcid.org/0009-0006-2628-0348)
- Tong Yu (ORCID: https://orcid.org/0009-0002-9463-9085)
Institutions
- Chinese Academy of Agricultural Sciences (CN)
- Jilin Agricultural University (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1186/s12985-025-02787-7
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00