Enhancing radiosensitivity of osteosarcoma by ITGB3 knockdown: a mechanism linked to enhanced osteogenic differentiation status through JNK/c-JUN/RUNX2 pathway activation
Our findings indicate that ITGB3-KD enhances radiosensitivity in osteosarcoma by promoting osteogenic differentiation and apoptosis through activation of the JNK/c-JUN/RUNX2 pathway, identifying ITGB3 as a candidate therapeutic target and implicating JNK/c-JUN/RUNX2 signaling as a modulatory axis for improving the response to radiation of osteosarcoma.
Authors
- Bingxuan Wang (ORCID: https://orcid.org/0009-0007-2150-3802)
- Peijun Dai
- Suchi Qiao
- Xin Jiang (ORCID: https://orcid.org/0000-0002-7288-8278)
- Qiujian Lian
- Haonan Zhao (ORCID: https://orcid.org/0009-0007-4125-2043)
- Chang Liu (ORCID: https://orcid.org/0000-0003-0776-6984)
- Zhiwei Wang (ORCID: https://orcid.org/0000-0001-5643-9344)
- Cheng Luo (ORCID: https://orcid.org/0009-0003-2405-1662)
- Jingyan Li
- Hu Liu (ORCID: https://orcid.org/0000-0002-3560-386X)
- Huifang Zhou (ORCID: https://orcid.org/0000-0002-9714-0709)
Institutions
- Naval Medical Research Command (US)
- Naval University of Engineering (CN)
- Shanghai Changzheng Hospital (CN)
- Fuzhou Second Hospital (CN)
- Fujian Provincial Hospital (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1186/s13046-025-03417-4
- Citations
- 4
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China