SENP5 promotes endometrial cancer cell growth by regulating β-catenin deSUMOylation to enhance GPX4-resistance to ferroptosis
SENP5 promotes GPX4-mediated ferroptosis resistance, thereby enhancing the proliferation of EC cells by regulating β-catenin desumoylation, this finding indicates that SENP5 may serve as a promising target for therapeutic interventions in the treatment of EC.
Authors
- Yandong Xi
- Qiuhong Deng
- Wanxia He
- Xiaolong Ma (ORCID: https://orcid.org/0000-0003-1392-2787)
- Ziyuan Wang (ORCID: https://orcid.org/0000-0002-7095-8527)
- Yong Zhang (ORCID: https://orcid.org/0000-0002-5831-637X)
- Yongmei Zhang
Institutions
- Yinchuan First People's Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1186/s40001-025-02662-9
- Citations
- 2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61