Poliumoside alleviates microglia-mediated inflammation and blood-brain barrier disruption via modulating the polarization of microglia after ischemic stroke in mice
Pol regulates microglial polarization in ischemic stroke by down-regulating JAK/STAT3 signaling pathway, alleviating the microglia-mediated inflammatory response and the destruction of blood-brain barrier.
Authors
- Yuxiao Gao
- Huan Wang (ORCID: https://orcid.org/0000-0002-4057-1145)
- Cong Zhang (ORCID: https://orcid.org/0000-0003-4284-938X)
- Bin Wang (ORCID: https://orcid.org/0000-0001-9422-5750)
- Xiangjian Zhang (ORCID: https://orcid.org/0000-0003-0114-1668)
- Jingjing Wang (ORCID: https://orcid.org/0000-0002-8760-8822)
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
- Hebei University of Chinese Medicine (CN)
- Air Force General Hospital PLA (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1016/j.phymed.2025.156881
- Citations
- 8
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 6.74