Egg exosome miR-145-5p decreases mitochondrial ROS to protect chicken embryo hepatocytes against apoptosis through targeting MAPK10
Exosome miR-145-5p in eggs could target MAPK10 and decrease mitochondrial ROS, attenuating oxidative damage and apoptosis in hepatocytes of chick embryos. These findings may provide new theoretical basis for the improvement of maternal physiological status to maintain embryonic redox homeostasis by nutritional or genetic modifications.
Authors
- Fengdong Zhang
- Boya Guo
- Yong Han (ORCID: https://orcid.org/0000-0002-6635-3920)
- Yongyan Jin
- Yuna Min (ORCID: https://orcid.org/0000-0001-6656-2231)
- Jian Chen (ORCID: https://orcid.org/0000-0001-7535-6499)
- Fan Li (ORCID: https://orcid.org/0000-0003-2584-3162)
- Hui Ma
- Wenchuan Zhou (ORCID: https://orcid.org/0000-0003-2978-7292)
- Pan Xiao
- Jia Feng
Institutions
- Northwest A&F University (CN)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1186/s40104-025-01203-y
- Citations
- 4
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 3.75
Funders
- National Natural Science Foundation of China