Investigating the Presence of Neurodegeneration Independent of Relapses in MOGAD Compared to Relapsing-Remitting Multiple Sclerosis
Neurodegeneration and progression independent of relapse activity (PIRA) are features of multiple sclerosis (MS), but their presence in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) is unclear. The aim of this study was to investigate neurodegeneration in MOGAD, independent of relapses, by comparing clinical, cognitive, and advanced MRI markers in MOGAD, relapsing-remitting MS (RRMS), and healthy control (HC).
Authors
- Francesca B. Pizzini (ORCID: https://orcid.org/0000-0002-6285-0989)
- Agnese Tamanti (ORCID: https://orcid.org/0000-0001-9972-4348)
- Gabriele Carmine DeLuca (ORCID: https://orcid.org/0000-0003-0342-5197)
- Pietro Bontempi (ORCID: https://orcid.org/0000-0002-7720-8243)
- Alessandro Daducci (ORCID: https://orcid.org/0000-0002-4677-6678)
- Ruth Geraldes (ORCID: https://orcid.org/0000-0001-5829-808X)
- Maria Isabel Leite (ORCID: https://orcid.org/0000-0002-4277-9855)
- Lorenzo S. Petralia (ORCID: https://orcid.org/0000-0002-9259-3231)
- Valentina Camera (ORCID: https://orcid.org/0000-0002-4925-9000)
- Marco Pitteri (ORCID: https://orcid.org/0000-0001-8093-4548)
- Massimiliano Calabrese (ORCID: https://orcid.org/0000-0002-3362-7403)
- Ludovica Griffanti (ORCID: https://orcid.org/0000-0002-0540-9353)
- Silvia Messina (ORCID: https://orcid.org/0000-0002-1134-5771)
- Maddalena Guandalini (ORCID: https://orcid.org/0000-0003-2341-9253)
- Jacqueline A. Palace (ORCID: https://orcid.org/0000-0003-4779-6133)
Institutions
- University of Verona (IT)
- University of Oxford (GB)
- Wellcome Centre for Integrative Neuroimaging (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
Publication Details
- Journal
- Neurology Open Access
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1212/wn9.0000000000000013
- Citations
- 4
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.89