Photon-counting computed tomography in esophageal cancer: correlation of iodine concentration with histopathology and treatment response to neoadjuvant radiochemotherapy
Question Does photon-counting CT-derived iodine concentration correlate with key histopathological features in esophageal cancer and predict response to neoadjuvant radiochemotherapy? Findings Photon-counting CT-derived normalized iodine concentration in esophageal adenocarcinoma moderately predicted treatment response, despite no correlation with tumor grade or Ki-67. Clinical relevance Normalized iodine concentration values from photon-counting CT, obtained during routine staging exams, offer an objective method for predicting treatment response in esophageal adenocarcinoma, enabling more precise therapy planning and personalized patient management.
Authors
- Saher Saeed (ORCID: https://orcid.org/0000-0001-9360-3131)
- Andreas Wienke (ORCID: https://orcid.org/0000-0001-5871-2586)
- Jan Borggrefe (ORCID: https://orcid.org/0000-0003-2908-7560)
- Alexey Surov (ORCID: https://orcid.org/0000-0002-9273-3943)
- Nina Pauline Haag (ORCID: https://orcid.org/0000-0002-8598-1295)
- Raihanatou Danebrock
- Julius Henning Niehoff (ORCID: https://orcid.org/0000-0003-0103-3819)
- Berthold Gerdes (ORCID: https://orcid.org/0000-0002-8661-6986)
- Jan Robert Kröger (ORCID: https://orcid.org/0000-0003-1218-7610)
- Ulrich Klaus Fetzner
- Pascal Bodin
Institutions
- University Hospitals of the Ruhr-University of Bochum (DE)
- Siemens (United States) (US)
- Siemens Healthcare (United States) (US)
- Johannes Wesling Klinikum Minden (DE)
- Martin Luther University Halle-Wittenberg (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- European Radiology
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1007/s00330-025-11683-1
- Citations
- 1
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.01