Early mobilization in postoperative glioma patients real world impact on recovery and long term prognosis

The implementation of early mobilization in postoperative care has been shown to expedite patient recovery. However, its widespread use among patients undergoing glioma resection is not firmly established. This study aimed to implement an early mobilization protocol in glioma patients and evaluate its effects on early recovery and long-term prognosis. Patients who underwent craniotomy for glioma treatment between January 2018 and December 2019 were enrolled in a randomized controlled trial comparing conventional perioperative care (control group) with conventional care plus a structured early mobilization protocol (experimental group). We collected data on early recovery and long-term prognosis from patients' electronic health records. Means and frequencies were evaluated using the Mann-Whitney U test, T-test, and chi-square test. The research team conducted standardized assessments in advance to ensure consistency. Postoperative primary outcomes revealed that the experimental group showed improvements of 39.06 points in activities of daily living and 0.86 points in numerical rating scale scores for pain, a 2.02 day shorter mean length of hospital stay (95% confidence interval [CI] 91.099-100.596, 0.403-1.691, 9.754-15.060, P < 0.001). Secondary outcomes also indicated that the experimental group had a 4.2 day shorter mean time to ambulation, a 3.48 day shorter mean duration of central venous catheter use, a 4.15 day shorter mean duration of gastric tube use, and a 3.64 day shorter mean duration of urethral catheter use. Furthermore, the experimental group demonstrated a significantly lower incidence of postoperative complications and reduced hospitalization expenses (P < 0.05). However, no statistically significant differences with secondary outcomes were observed in intraoperative blood loss or three-year prognosis between the two groups. Our findings show that an early mobilization protocol can promote early recovery in patients undergoing glioma resection without adversely affecting long-term prognosis. The protocol demonstrated both safety and cost-effectiveness, supporting its clinical implementation to improve postoperative functional recovery.