USO DE ANTIDEPRESSIVOS NA GESTAÇÃO E TRANSTORNO DO ESPECTRO AUTISTA NA PROLE: UMA REVISÃO SISTEMÁTICA

INTRODUCTION: ASD is a neurodevelopmental disorder with social and communication deficits and stereotypes. External factors in ASD have been questioned. This systematic review analyzed studies up to October 2023 on prenatal AD and the onset of ASD. METHODS: The databases used were PubMed, Cochrane and VHL. RESULTS: Seven articles met the selected criteria: AD use, prenatal period, symptoms and diagnosis in the offspring, five were in humans and two in animals. This is a significant number of patients. There is disagreement in the results, most of which rule out the relationship. Brennan, 2022 points out that it does exist. They found more depressive offspring, ADHD and a correlation with the 16p11.2 deletion. The animal studies describe anxiety.DISCUSSION: Animal studies show behavioral changes characteristic of ASD (rejection of social interaction and repetitive behaviors). Human studies agree that there are higher rates of ASD diagnosis in the children of women with psychiatric disorders, especially major depression. Individual studies have revealed high symptom scores in children exposed to SSRIs in the womb and the use of SSRIs with higher rates of ADHD.CONCLUSION: There is an association with an increased risk of cognitive and emotional disorders. There is disagreement as to the affirmation of this relationship, but it is found. Further studies are recommended. Keywords (Palavras-chave em Inglês): Antidepressants; Autism Spectrum Disorder; Pregnant Women.