Intergenerational Postoperative Neurocognitive Disorder in a Rat Model: Initiating Mechanisms and Pharmacological Prevention
These findings suggest a role for hypothalamic NKCC1/γ-aminobutyric acid type A receptor/AVP signaling in sevoflurane-triggered PND in adult male rats, which also affects their future sevoflurane-unexposed offspring. NKCC1 and glucocorticoid receptors could serve as therapeutic targets for prevention of sevoflurane-induced PND in exposed rats and in their future offspring.
Authors
- Anatoly E. Martynyuk (ORCID: https://orcid.org/0000-0002-9915-5584)
- Barry Setlow (ORCID: https://orcid.org/0000-0001-9133-9445)
- Zeeshan Ahmad Khan (ORCID: https://orcid.org/0000-0002-0737-0253)
- Nikolaus Gravenstein (ORCID: https://orcid.org/0000-0002-3884-1564)
- Christoph N. Seubert (ORCID: https://orcid.org/0000-0003-4502-4201)
- Ling-Sha Ju (ORCID: https://orcid.org/0000-0001-7266-0794)
Institutions
- University of Florida (US)
- Florida College (US)
Publication Details
- Journal
- Anesthesiology
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1097/aln.0000000000005578
- Citations
- 1
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 1.32