LL-37 and citrullinated-LL-37 modulate IL-17A/F-mediated responses and selectively suppress Lipocalin-2 in bronchial epithelial cells
Overall, our findings showed that LL-37 and citLL-37 can selectively suppress the abundance of IL-17A/F-mediated LCN-2, a protein that is critical for neutrophil migration in HBEC. These results suggest that LL-37, and its modified citrullinated form, have the potential to negatively regulate IL-17-mediated neutrophil migration during airway inflammation. To our knowledge, this is the first study to report that the immunomodulatory function of LL-37 enhances the RNA binding protein Regnase-1, suggesting that a post-transcriptional mechanism of action is mediated by the peptide.
Authors
- Anthony Altieri (ORCID: https://orcid.org/0000-0001-6799-196X)
- Anne M. van der Does (ORCID: https://orcid.org/0000-0002-1613-106X)
- Neeloffer Mookherjee (ORCID: https://orcid.org/0000-0002-9350-4157)
- Mahadevappa Hemshekhar (ORCID: https://orcid.org/0000-0002-5016-501X)
- Dylan Lloyd
- Padmanie Ramotar
Institutions
- University of Toronto (CA)
- Leiden University Medical Center (NL)
- University of Manitoba (CA)
Publication Details
- Journal
- Journal of Inflammation
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1186/s12950-025-00446-w
- Citations
- 4
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 4.73
Funders
- Research Manitoba
- Reseau canadien de recherche respiratoire
- Children's Hospital Research Institute of Manitoba
- Natural Sciences and Engineering Research Council of Canada