Mechanism of Action and Efficacy of Wu-Hua-Yan-Xiao in the Treatment of Pediatric Acute Pharyngitis Based on Network Pharmacology and Experimental Validation
The WHYX formula alleviates inflammation, reduces apoptosis, and protects pharyngeal tissue in young rats with acute pharyngitis. Aerosol inhalation of WHYX presents a direct, effective, and non-invasive strategy for pediatric acute pharyngitis management.
Authors
- Zihao Shen (ORCID: https://orcid.org/0000-0002-8092-5956)
- Junqiu Luo (ORCID: https://orcid.org/0000-0002-1024-1866)
- Wanghua Liu (ORCID: https://orcid.org/0009-0001-4877-7930)
- Caixing Zheng (ORCID: https://orcid.org/0009-0008-3990-3318)
- Xinyun Zhang (ORCID: https://orcid.org/0009-0005-1464-9083)
- Zengyu Zhang (ORCID: https://orcid.org/0000-0001-5333-9911)
- Jinxia Li (ORCID: https://orcid.org/0000-0002-0949-8365)
- Ying‐zi Xu (ORCID: https://orcid.org/0009-0001-7733-6114)
- Hao Liang (ORCID: https://orcid.org/0000-0003-3150-1919)
- Yidi Zeng
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
- Jinshan Hospital of Fudan University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/dddt.s513073
- Citations
- 1
- Primary Topic
- Streptococcal Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.88