Hepatic Steatosis and Stiffness in Adolescent Obesity are Linked to Androgenemia, Insulin Sensitivity, and Inflammation
HFF was higher in girls with PCOS versus those without, but not different from boys. While stiffness did not differ by group, its association with testosterone concentrations in girls without PCOS may be an additional risk biomarker for MASLD in addition to inflammation and insulin resistance. Future larger, longitudinal studies should determine if addressing these alterations, separately or collectively, in youth with obesity could improve hepatic outcomes.
Authors
- Mary Ellen Vajravelu (ORCID: https://orcid.org/0000-0002-5839-7923)
- Sameh Tadros
- Theresa Stauffer
- Nabiha Shahid
- James E. Squires (ORCID: https://orcid.org/0000-0001-6979-8987)
- Marianne Chebli (ORCID: https://orcid.org/0000-0002-1290-2293)
- Selma F. Witchel (ORCID: https://orcid.org/0000-0001-5178-5897)
- Silva Arslanian
Institutions
- Phoenix Children's Hospital (US)
- Children's Hospital of Pittsburgh (US)
Publication Details
- Journal
- Hormone Research in Paediatrics
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1159/000546577
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42