Prognostic Role of PD-L1 and IDO-1 Expression in Sinonasal Carcinoma
The study identifies PD-L1 and IDO-1 as possible prognostic factors for sinonasal SCC, but less so for sinonasal AC. A TPS score >50% and combined low IDO-1 score correlate with shortened 3-year PFS and OS in sinonasal SCC. Immune checkpoints could, therefore, represent important target molecules for the prognosis assessment of sinonasal SCC.
Authors
- Claudia Rudack (ORCID: https://orcid.org/0000-0002-2202-9504)
- Felix Heitkötter (ORCID: https://orcid.org/0000-0002-8356-0008)
- Armands Riders
- Maximilian Oberste (ORCID: https://orcid.org/0000-0001-6699-1933)
- Philipp Donatus Göttker
- Daria Rometsch
- Frank A. Simon
Institutions
- University Hospital Münster (DE)
Publication Details
- Journal
- ORL
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1159/000546118
- Primary Topic
- Head and Neck Surgical Oncology
- Type
- article
- Field-Weighted Citation Impact
- 0.00