Identification of Age- and Cataract-Related Changes in High-Density Lens Protein Aggregates
Binding of crystallin aggregates to human lens cell membranes is associated with protein truncation, deamidation, and isomerization, and was observed in normal aged and cataract lenses. However, the protein aggregates bound to membranes in cataract lenses exhibit distinct modifications to γ-crystallins that may arise as a consequence of additional protein degradation.
Authors
- Kevin L. Schey (ORCID: https://orcid.org/0000-0002-3959-1712)
- Zhen Wang (ORCID: https://orcid.org/0000-0002-9993-1889)
- Michael G. Friedrich (ORCID: https://orcid.org/0000-0002-8274-1552)
- Roger J.W. Truscott
Institutions
- Vanderbilt University (US)
- University of Wollongong (AU)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1167/iovs.66.5.34
- Citations
- 6
- Primary Topic
- Connexins and lens biology
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Institutes of Health