Ageing alters zinc, magnesium, and interleukin-8 levels in human dermal fibroblasts
Reduced interleukin-8 secretion compromises immune regulation in ageing skin. Elevated free zinc ion levels and zinc transporter expression contribute to eventual cellular zinc loss, impairing inflammatory responses and weakening immunity. These findings highlight the critical role of zinc and magnesium micronutrient balance in maintaining skin health during ageing.
Authors
- Wolfgang Maret (ORCID: https://orcid.org/0000-0003-1458-8231)
- Richard Siow (ORCID: https://orcid.org/0000-0003-4603-9763)
- Ranjit K. Bhogal (ORCID: https://orcid.org/0000-0003-4835-4871)
- Nor Balkish Zakaria (ORCID: https://orcid.org/0000-0002-1795-9854)
- David J. Messenger (ORCID: https://orcid.org/0009-0008-0935-2519)
- Matthew J. Smith (ORCID: https://orcid.org/0000-0002-6333-0141)
Institutions
- Unilever (United Kingdom) (GB)
- King's College London (GB)
- British Heart Foundation (GB)
Publication Details
- Journal
- Journal of Trace Elements in Medicine and Biology
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1016/j.jtemb.2025.127673
- Citations
- 1
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 1.12
Funders
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council