PERK Regulates Epithelial–Mesenchymal Transition Through Autophagy and Lipid Metabolism in Lens Epithelial Cells
ER stress, particularly the PERK axis, promotes LECs' EMT through autophagy and PE metabolism, offering potential therapeutic targets for the treatment of lens fibrosis.
Authors
- Baoxin Chen
- Mi Huang (ORCID: https://orcid.org/0000-0001-9469-5533)
- Shan Huang (ORCID: https://orcid.org/0000-0001-8492-9658)
- Jieping Chen (ORCID: https://orcid.org/0000-0001-9666-2911)
- Xiaoran Wang (ORCID: https://orcid.org/0000-0003-4827-6930)
Institutions
- Sun Yat-sen University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1167/iovs.66.5.35
- Citations
- 2
- Primary Topic
- Connexins and lens biology
- Type
- article
- Field-Weighted Citation Impact
- 1.61