Targeting the bile acid receptor TGR5 with Gentiopicroside to activate Nrf2 antioxidant signaling and mitigate Parkinson’s disease in an MPTP mouse model
These findings collectively indicated that GPS targeted TGR5 to activate Nrf2 antioxidant signaling and ultimately ameliorated the pathological progression of PD.
Authors
- Ming Zhao (ORCID: https://orcid.org/0000-0002-7539-3887)
- Xiuling Tang
- Ying Gao (ORCID: https://orcid.org/0000-0003-0696-7880)
- Le Yang
- Ting Sun (ORCID: https://orcid.org/0000-0001-8287-0541)
- An Liu (ORCID: https://orcid.org/0000-0003-3316-5496)
- Yue Chen (ORCID: https://orcid.org/0000-0003-0832-7801)
- Bao Wang (ORCID: https://orcid.org/0000-0001-9689-3891)
- Caiyan Cheng
- Jingcheng Yang
- Jingyue Yao
Institutions
- Tang Du Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1016/j.jare.2025.05.039
- Citations
- 6
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 6.27