Biomedical Assessment of ZnO, MnO and Se Nanoparticles Synthesized via Laser-Induced Plasma: Effects on Thyroid Hormone Levels

In this study, nanoparticles were synthesized using the pulsed laser ablation technique, employing an Nd:YAG laser with a wavelength of 1064 nm. The ablation process was carried out at room temperature under varying laser energy of 950 mJ. The structural characteristics of the resulting nanoparticles were investigated using X-ray diffraction (XRD) and atomic force microscopy (AFM). The biological impact of the synthesized nanoparticles was assessed by administering two different doses (1 ml/kg and 4 ml/kg) to experimental animal models. The study evaluated changes in thyroid hormone levels, specifically thyroid-stimulating hormone (T SH ), triiodothyronine (T[Formula: see text] and thyroxine (T[Formula: see text]. Variations in hormone concentrations were observed, including increases and decreases in T SH , T 3 and T 4 levels, depending on the administered dose. Additionally, the relative body weight of the rats was monitored throughout the experimental period, providing insights into the influence of the nanoparticles on metabolic activity.