Penetrance of Neurodevelopmental Copy Number Variants Is Associated With Variations in Cortical Morphology

Our findings link global and regional cortical morphometric features with CNV penetrance, providing new insights into neurobiological mechanisms of genetic risk for schizophrenia and other developmental disorders.

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Journal
Biological Psychiatry Cognitive Neuroscience and Neuroimaging
Published
2025-05-23
DOI
https://doi.org/10.1016/j.bpsc.2025.05.010
Citations
1
Primary Topic
Genomic variations and chromosomal abnormalities
Type
article
Field-Weighted Citation Impact
1.82

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article

Penetrance of Neurodevelopmental Copy Number Variants Is Associated With Variations in Cortical Morphology

Andreas Heinz, Hugh P Garavan, Anbupalam Thalamuthu, Lars Tjelta Westlye et al.
1 citations
Biological Psychiatry Cognitive Neuroscience and Neuroimaging
Genomic variations and chromosomal abnormalities
1.82
article

Penetrance of Neurodevelopmental Copy Number Variants Is Associated With Variations in Cortical Morphology

Andreas Heinz, Hugh P Garavan, Anbupalam Thalamuthu, Lars Tjelta Westlye, Ariana Vajdi, John Blangero, Katie L. McMahon, Derek Kenton Jones, Erik G. Jönsson, Stéphanie Le Hellard, Naomi J. Goodrich‐Hunsaker, Rachel K. Jonas, Ana Isabel Silva, Sarah Elizabeth Medland, Carrie E. Bearden, Paola Dazzan, Kieran C. Murphy, Gary J Donohoe, Tobias Banaschewski, Ingrid Agartz, Abdel Abdellaoui, Sophia I. Thomopoulos, Neda Jahanshad, Ole A. Andreassen, Thérèse van Amelsvoort, Sarah Hohmann, Allan F. McRae, Michael J. Owen, Robin Bülow, Clara Moreau, Marie‐Laure Paillère Martinot, Robin M. Murray, Karen A. Mather, Rune Bøen, J. Eric Schmitt, Vince D. Calhoun, Shareefa Dalvie, Javier Vázquez-Bourgón, Greig I. de Zubicaray, Ida E. Sønderby, Dennis van ‘t Ent, David R. Roalf, Perminder Singh Sachdev, Simone Ciufolini, Donna M. McDonald‐McGinn, Jacob Vorstman, Declan Murphy, David E.J. Linden, Joanne Doherty, Antoine Grigis, Sanne Koops, George Kirov, Linda Campbell, Anne Uhlmann, Maria Gudbrandsen, Margaret J. Wright, Jan Haavik, Astri J. Lundervold, Asta Kristine Haberg, Paul R. Thompson, Lachlan T. Strike, Hervé Lemaître, Mark Drakesmith, Dimitri Papadopoulos Orfanos, Eileen Daly, Michael Craig, Julio E. Villalón‐Reina, Dan Joseph Stein, Nigel Williams, Adam Cunningham, David C. Glahn, Nancy J. Butcher, Frauke Nees, Sébastien Jacquemont, Eco J. C. de Geus, Nicola J. Armstrong, Katharina Wittfeld, Tiago Reis Marques, Freda Scheffler, Vincent Frouin, Dorret Irene Boomsma, Boris A. Gutman, Penny Anne Gowland, Uwe Völker, Eric Artiges A, Diana Tordesillas‐Gutiérrez, Marianne B. M. van den Bree, Jingyu Liu, Arvind Kumar, Jeremy Hall, Dennis van der Meer, Günter Schumann, Alexander Teumer, Eva W.C. Chow, Tomaš Paus, Henry Völzke, Luise Poustka, Jouke-Jan Hottenga, Anne S. Bassett, David Ames, Julian N Trollor, Jean-Luc Martinot, Vidar M. Steen, Hans J. Grabe, Thomas Espeseth, Benedicto Crespo-Farroco
article en
1 citations

Abstract

Our findings link global and regional cortical morphometric features with CNV penetrance, providing new insights into neurobiological mechanisms of genetic risk for schizophrenia and other developmental disorders.

Biological Psychiatry Cognitive Neuroscience and NeuroimagingVol. 10(10)
South African Medical Research Council (ZA), University of Vermont (US), University of Southern California (US), Oslo University Hospital (NO), Boston Children's Hospital (US), Centre National de la Recherche Scientifique (FR), Georgia Institute of Technology (US), New South Wales Department of Health (AU), Universidad de Cantabria (ES), University Health Network (CA), University Medical Center Groningen (NL), Children's Hospital of Philadelphia (US), Centre for Addiction and Mental Health (CA), University of Nottingham (GB), Royal College of Surgeons in Ireland (IE), Emory University (US), Université de Bordeaux (FR), Inserm (FR), University of Cape Town (ZA), Universität Hamburg (DE), Queensland University of Technology (AU), University of California, Los Angeles (US), The University of Queensland (AU), The University of Melbourne (AU), Illinois Institute of Technology (US), King's College London (GB), OsloMet – Oslo Metropolitan University (NO), University of Oslo (NO), University of Toronto (CA), Ollscoil na Gaillimhe – University of Galway (IE), Norwegian University of Science and Technology (NO), Curtin University (AU), QIMR Berghofer Medical Research Institute (AU), University of Utah (US), Heidelberg University (DE), Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR), Université Paris-Saclay (FR), Universitätsmedizin Greifswald (DE), Haukeland University Hospital (NO), Hammersmith Hospital (GB), University Hospital Heidelberg (DE), The University of Texas Rio Grande Valley (US), Centre Hospitalier Universitaire Sainte-Justine (CA), Department of Health and Aged Care (AU), UNSW Sydney (AU), Christian-Albrechts-Universität zu Kiel (DE), Maastricht University (NL), Humboldt-Universität zu Berlin (DE), Sorbonne Université (FR), Institut des Maladies Neurodégénératives (FR), Public Health Wales (GB), Centro de Investigación Biomédica en Red de Salud Mental (ES), Assistance Publique – Hôpitaux de Paris (FR), Marqués de Valdecilla University Hospital (ES), Central Institute of Mental Health (DE), Amsterdam Neuroscience (NL), University Medical Center Hamburg-Eppendorf (DE), Instituto de Investigación Marqués de Valdecilla (ES), Universitätsmedizin Göttingen (DE), Diakonhjemmet Hospital (NO), Pitié-Salpêtrière Hospital (FR), CEA Paris-Saclay (FR), Instituto de Biomedicina de Sevilla (ES), Center for Translational Research in Neuroimaging and Data Science (US), Stockholm Health Care Services (SE), SickKids Foundation (CA), Hamad bin Khalifa University (QA), Institute for Clinical Evaluative Sciences (CA), Laboratoire de Biologie et Pharmacologie Appliquée (FR), Amsterdam University Medical Centers (NL), Instituto de Física de Cantabria (ES), Hospital Universitario Virgen del Rocío (ES), Cognitive Research (United States) (US), Einstein Center for Neurosciences Berlin (DE), MRC London Institute of Medical Sciences (GB), Shanghai Center for Brain Science and Brain-Inspired Technology (CN), University of Bergen (NO), Charles R. Drew University of Medicine and Science (US), Université de Montréal (CA), Technische Universität Dresden (DE), University of Newcastle Australia (AU), Cardiff University (GB), University of Pennsylvania (US), Neuroscience Research Australia (AU), Vrije Universiteit Amsterdam (NL), University of the Western Cape (ZA), University of Amsterdam (NL), University of Wales (GB)
National Science Foundation, Foundation for the National Institutes of Health, Autism Speaks, Biogen, University of Southern California, Charles R. Drew University of Medicine and Science, Children's Hospital of Philadelphia, University of Pennsylvania, Emory University, Fondation de l'Avenir pour la Recherche Médicale Appliquée, Qatar Foundation, University of Utah, Georgia State University, McGill University, Universidad de Sevilla, Norges Teknisk-Naturvitenskapelige Universitet, Fondation Brain Canada, Sunovion, University of Roehampton, Wellcome Trust, Neuroscience Research Australia, Royal College of Surgeons in Ireland, Compute Canada, QIMR Berghofer Medical Research Institute, European Federation of Pharmaceutical Industries and Associations, Simons Foundation Autism Research Initiative, Public Health Wales, Australian Government, Psychiatry Research Trust, Universitätsmedizin Göttingen, Hamad Bin Khalifa University, Natera, National Institute for Health and Care Research, Imperial College London, King's College London, University of Oxford, European Commission, Cardiff University, South African Medical Research Council, Science Foundation Ireland, University of Galway, Deutsche Forschungsgemeinschaft, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, Rijksuniversiteit Groningen, Koninklijke Nederlandse Akademie van Wetenschappen, University of New South Wales, Queensland University of Technology, University of Queensland, National Natural Science Foundation of China, ZonMw, Vrije Universiteit Amsterdam, Bundesministerium für Bildung und Forschung, Fondation pour la Recherche Médicale, Technische Universität Dresden, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Fudan University, University of Toronto, Department of Health and Aged Care, Australian Government, Karolinska Institutet, Khalifa University of Science, Technology and Research, Helse Vest, Stockholms Läns Landsting, Vetenskapsrådet, Fondation de France, Helse Midt-Norge, Centre National de la Recherche Scientifique, Astellas Pharma, Universitetet i Bergen, Universitair Medisch Centrum Groningen, Universitetet i Oslo, Norges Forskningsråd, Hospital for Sick Children, Humboldt-Universität zu Berlin, Université de Bordeaux, Universidad de Cantabria, Fédération pour la Recherche sur le Cerveau, Bergens Forskningsstiftelse, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, University of Cape Town, Université Paris-Saclay, Freie Universität Berlin, Assistance publique-Hôpitaux de Paris, Haukeland Universitetssjukehus, Canada First Research Excellence Fund, Siemens Healthineers, Servier, H. Lundbeck A/S, Centre for Medical Systems Biology, Norwegian Biodiversity Information Centre, Instituto de Investigación Marqués de Valdecilla, Universität Greifswald, Sorbonne Université, Société d'Accélération du Transfert de Technologies, Instituto de Física de Cantabria, Avera Institute for Human Genetics, New South Wales Government, Sickkids Research Institute, Ministry of Cultural Affairs, National Institutes of Health, Perelman School of Medicine, University of Pennsylvania, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Canadian Institutes of Health Research, Medical Research Council, National Health and Medical Research Council, Instituto de Salud Carlos III, Queensland Brain Institute, Helse Sør-Øst RHF, School of Psychology, Cardiff University, Helmholtz Zentrum München, Faculty of Medicine and Health, University of Sydney, Norwegian Institute of Public Health, National Institute of Mental Health, National Institute of Child Health and Human Development, Stanford Maternal and Child Health Research Institute, H2020 European Research Council, FP7 Health, Cilag
Gender equality
Openalex Percentile: Top 16%
Genomic variations and chromosomal abnormalities
1.82
DOIOpen Access PDFOpenAlex
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