A Novel Liquid Chromatography–Tandem Mass Spectrometry Method for Monitoring Plasma l-Asparaginase Activity in Pediatric Patients With Acute Lymphoblastic Leukemia Receiving Pegaspargase Treatment
This method was fully validated and successfully applied to quantify l -asparaginase activity in plasma samples of 15 children with ALL, enabling the monitoring of l -asparaginase activity with mass spectrometry.
Authors
- Xuepeng Gong (ORCID: https://orcid.org/0000-0003-0099-2938)
- Qun Hu (ORCID: https://orcid.org/0000-0002-1508-2796)
- Dong Xiang (ORCID: https://orcid.org/0000-0001-7312-3798)
- Hengyi Yu (ORCID: https://orcid.org/0000-0002-5412-5293)
- Lu Liu (ORCID: https://orcid.org/0000-0002-1547-4431)
- Dong Liu (ORCID: https://orcid.org/0000-0002-2928-3548)
- Zhen Wang (ORCID: https://orcid.org/0000-0001-5334-1544)
- Yaqin Wang (ORCID: https://orcid.org/0000-0003-4373-7435)
- Aiguo Liu (ORCID: https://orcid.org/0000-0002-8541-1671)
- Guangjie Yang
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Therapeutic Drug Monitoring
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1097/ftd.0000000000001345
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Hubei Province
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province