Chronic mild stress disrupts mitophagy and mitochondrial status in rat frontal cortex
There is a dysregulation of mitochondrial dynamics towards fusion, an upregulation of mitophagy markers, and the induction of genes associated with mitochondrial biogenesis in response to CMS in the frontal cortex of adult rats. This study highlights the impact of psychological stress on brain mitochondrial networks.
Authors
- Karina S. MacDowell (ORCID: https://orcid.org/0000-0002-1527-8895)
- Álvaro G. Bris (ORCID: https://orcid.org/0000-0002-4440-3755)
- Borja García‐Bueno (ORCID: https://orcid.org/0000-0001-7320-1530)
- Javier R. Caso (ORCID: https://orcid.org/0000-0001-8622-749X)
- Cristina Ulecia-Morón (ORCID: https://orcid.org/0000-0003-1322-644X)
- Juan Carlos Leza (ORCID: https://orcid.org/0000-0002-9901-0094)
- José L. M. Madrigal (ORCID: https://orcid.org/0000-0002-1409-9561)
Institutions
- Instituto de Salud Carlos III (ES)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1186/s12967-025-06604-1
- Citations
- 9
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- Ministerio de Ciencia, Innovación y Universidades
- European Commission
- Universidad Complutense de Madrid
- Ministerio de Ciencia e Innovación
- Centro de Investigación Biomédica en Red de Salud Mental
- Instituto de Salud Carlos III
- European Regional Development Fund
- Agencia Estatal de Investigación