Mechanistic rules for de novo design of enzymes
Designing how to give direction to chemistry as emergent property via a bifurcation Model built on two pillars: momentum conservation and dissipative coupling We discover a novel mechanism not accessible to Kramers- like energy-barrier crossing We identify three golden rules for the optimal function of a fueled enzyme
Authors
- Michalis Chatzittofi (ORCID: https://orcid.org/0009-0007-3898-3638)
- Ramin Golestanian (ORCID: https://orcid.org/0000-0002-3149-4002)
- Jaime Agudo‐Canalejo (ORCID: https://orcid.org/0000-0001-9677-6054)
Institutions
- University of Oxford (GB)
- Max Planck Institute for Dynamics and Self-Organization (DE)
- University College London (GB)
Publication Details
- Journal
- Chem Catalysis
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1016/j.checat.2025.101394
- Citations
- 3
- Primary Topic
- Photosynthetic Processes and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Bundesministerium für Bildung und Forschung
- Max-Planck-Gesellschaft