Loss of SMARCA4 Leads to Intron Retention and Generation of Tumor-Associated Antigens in Small Cell Carcinoma of the Ovary, Hypercalcemic Type
SCCOHT, a rare ovarian cancer, features splicing dysregulation due to SMARCA4 loss that generates immunostimulatory peptides linked to potential immune responses and therapeutic avenues, challenging traditional views of the role of SMARCA4.
Authors
- Victoria Zismann (ORCID: https://orcid.org/0000-0003-3287-5779)
- Victoria David‐Dirgo
- Anthony N. Karnezis (ORCID: https://orcid.org/0000-0003-2924-1126)
- Marcin Kortylewski (ORCID: https://orcid.org/0000-0002-6003-1816)
- Elizabeth A. Raupach (ORCID: https://orcid.org/0000-0002-6034-007X)
- Jessica D. Lang (ORCID: https://orcid.org/0000-0001-9700-4785)
- William P.D. Hendricks
- Bernard E. Weissman (ORCID: https://orcid.org/0000-0002-1827-2309)
- Salvatore Facista (ORCID: https://orcid.org/0000-0002-4353-1149)
- Marice Alcantara (ORCID: https://orcid.org/0000-0003-1853-2884)
- Lorna Rodrı́guez-Rodrı́guez (ORCID: https://orcid.org/0000-0002-5909-1774)
- Krystal A. Orlando (ORCID: https://orcid.org/0000-0001-5790-8843)
- Apurva M. Hegde
- Jeffrey M. Trent (ORCID: https://orcid.org/0000-0003-0183-4202)
- D. L. ROSE (ORCID: https://orcid.org/0000-0003-1430-5692)
- Rebecca F. Halperin
- Ritin Sharma (ORCID: https://orcid.org/0000-0001-8365-9916)
- Lynda Bennett (ORCID: https://orcid.org/0000-0001-7491-5797)
- Krystine Garcia‐Mansfield (ORCID: https://orcid.org/0000-0002-9089-2254)
- Timothy G. Whitsett (ORCID: https://orcid.org/0000-0002-0447-5682)
- Patrick Pirrotte (ORCID: https://orcid.org/0000-0003-1360-6039)
- David G. Huntsman (ORCID: https://orcid.org/0000-0003-4934-3322)
- Yemin Wang (ORCID: https://orcid.org/0000-0002-2970-9510)
- Rochelle Kofman (ORCID: https://orcid.org/0000-0002-0163-9477)
- Zoe N. Jensen
- Rayvon Moore
Institutions
- University of North Carolina at Chapel Hill (US)
- Translational Genomics Research Institute (US)
- City Of Hope National Medical Center (US)
- University of Wisconsin–Madison (US)
- University of British Columbia (CA)
- City of Hope (US)
- Mayo Clinic in Arizona (US)
- Molecular Oncology (United States) (US)
- Arsenal Biosciences (United States) (US)
- Baylor Scott & White Health (US)
- University of California Davis Medical Center (US)
- Beckman Research Institute
- University of California, Davis (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1158/0008-5472.can-24-0044
- Citations
- 5
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- Division of Cancer Prevention, National Cancer Institute
- Baylor Scott and White Research Institute