Selective Glycopolymer Inhibitors of Galectin-3: Supportive Anti-Cancer Agents Protecting Monocytes and Preserving Interferon-Gamma Function
The prepared glycopolymers are promising inhibitors of Gal-3 and may serve as important supportive anti-cancer nanosystems enabling the infiltration of proinflammatory macrophages and the reprogramming of unwanted M2 macrophages into the M1 subtype.
Authors
- Michaela Hovorková (ORCID: https://orcid.org/0000-0003-0370-7936)
- Viktoria Heine (ORCID: https://orcid.org/0000-0002-8667-3059)
- Vladimı́r Křen (ORCID: https://orcid.org/0000-0002-1091-4020)
- Petr Chytil (ORCID: https://orcid.org/0000-0002-7135-9796)
- Marcela Filipová (ORCID: https://orcid.org/0000-0003-3503-7973)
- Tomáš Etrych (ORCID: https://orcid.org/0000-0001-5908-5182)
- Pavlína Nekvasilová (ORCID: https://orcid.org/0000-0002-3858-0042)
- Marina Rodrigues Tavares (ORCID: https://orcid.org/0000-0002-8099-4820)
- Pavla Bojarová
Institutions
- Czech Academy of Sciences (CZ)
- Charles University (CZ)
- Czech Academy of Sciences, Institute of Macromolecular Chemistry (CZ)
- Czech Academy of Sciences, Institute of Microbiology (CZ)
- Czech Technical University in Prague (CZ)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/ijn.s503381
- Citations
- 1
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- European Commission
- Grantová Agentura České Republiky