Aggregate index of systemic inflammation tied to increased fatty liver disease risk: insights from NHANES data
This study reveals a significant, independent association between elevated AISI and increased FLD risk in the U.S. population, even after adjusting for confounders. AISI demonstrated good discriminative performance for FLD, but its effect size suggests it should supplement, not replace, existing clinical risk assessment tools. AISI, a cost-effective biomarker, holds potential for enhancing FLD screening, particularly in resource-limited settings.
Authors
- Xiangling Li (ORCID: https://orcid.org/0000-0003-1152-2165)
- Yuan Yuan (ORCID: https://orcid.org/0000-0002-0097-3027)
- Chenglong Wang (ORCID: https://orcid.org/0000-0003-2024-1381)
- Meng Zhang (ORCID: https://orcid.org/0000-0002-3055-2813)
- You Min Huang
- Zujie Qin
- Peili Fan (ORCID: https://orcid.org/0000-0001-5649-495X)
Institutions
- Guangxi University (CN)
- Guangxi University of Chinese Medicine (CN)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1186/s12876-025-03998-6
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Natural Science Foundation of Guangxi Province