Role of Digoxin in Preventing Cigarette Smoke-Induced COPD via HIF-1α Inhibition in a Mouse Model
Digoxin can protect CS-induced COPD and prevent CS-induced EMT possibly through HIF-1α/TGF-β1/Smad3 signaling pathway in mice. This study suggests HIF1-α could be a potential intervention target for COPD prevention and treatment, especially for EMT in CS-induced COPD.
Authors
- Wenju Lu (ORCID: https://orcid.org/0000-0002-5035-9287)
- Jian Wang (ORCID: https://orcid.org/0000-0002-1278-256X)
- Defu Li (ORCID: https://orcid.org/0000-0002-6795-375X)
- Kedong Zhang (ORCID: https://orcid.org/0000-0001-6801-5928)
- Feng Zhou (ORCID: https://orcid.org/0000-0003-2252-7981)
- Caixia Zhu
- Yuan Liang (ORCID: https://orcid.org/0000-0002-0055-835X)
Institutions
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Ningxia Medical University (CN)
- Affiliated Hospital of Shaanxi University of Chinese Medicine (CN)
- Ningxia Medical University General Hospital (CN)
- Shaanxi Provincial Hospital of Traditional Chinese Medicine (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Shaanxi University of Chinese Medicine (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- International Journal of COPD
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/copd.s493856
- Citations
- 4
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- National Natural Science Foundation of China
- Education Department of Shaanxi Province