Fecal microbiota transplantation for hypertension: an exploratory, multicenter, randomized, blinded, placebo-controlled trial
Safety but unsustainable BP reduction was observed in the first trial of the effects of FMT on hypertension. Additional intervention studies on specific microbes with metabolite-targeting and BP-modulating features are needed. Video Abstract.
Authors
- Luyun Fan
- Youren Chen (ORCID: https://orcid.org/0000-0003-4401-3279)
- Jie Ren (ORCID: https://orcid.org/0000-0003-2599-9001)
- Junru Chen (ORCID: https://orcid.org/0000-0003-4553-6979)
- Lu Wang (ORCID: https://orcid.org/0000-0002-4398-122X)
- Zihong Guo
- Xiaoyan Liu (ORCID: https://orcid.org/0000-0002-1732-5923)
- Wenjie Wang (ORCID: https://orcid.org/0000-0002-5199-1428)
- Yang Wang (ORCID: https://orcid.org/0000-0001-8055-9522)
- Zhenzhen Chen (ORCID: https://orcid.org/0000-0002-6261-3684)
- Bingpo Zhu
- Qi Zhang (ORCID: https://orcid.org/0000-0002-6096-0690)
- Peili Bu (ORCID: https://orcid.org/0000-0003-2064-6450)
- Lemin Zheng (ORCID: https://orcid.org/0000-0003-4473-6936)
- Qiannan Gao
- Jun Cai (ORCID: https://orcid.org/0000-0001-7856-8614)
- Yan-Yan Zhao
- Jinfeng Yang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- University of Macau (MO)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Southern University of Science and Technology (CN)
- Shantou University (CN)
- Fuwai Yunnan Cardiovascular Hospital (CN)
- Reproductive & Genetic Hospital CITIC-Xiangya (CN)
- Beijing Anzhen Hospital (CN)
- Second Affiliated Hospital of Shantou University Medical College (CN)
- Shanxi Academy of Medical Sciences (CN)
- Qilu Hospital of Shandong University (CN)
- Fu Wai Hospital (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1186/s40168-025-02118-6
- Citations
- 19
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 26.53
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences
- China Academy of Chinese Medical Sciences
- Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support
- Beijing Municipal Science and Technology Commission
- National Science and Technology Major Project
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China