Impaired Glucagon Suppression Accompanied by Liver Fat Accumulation Mediated Worse Blood Glucose Control in Patients With T2D
Liver fat accumulation in T2D is strongly associated with defective postprandial glucagon suppression, particularly in males, which mediates nearly one-third of its detrimental impact on glycemic control. Targeting hepatic steatosis and glucagon signaling may offer novel therapeutic strategies for T2D management.
Authors
- Jingfei Liu
- Zhangyao Su
- Yiwen Zhou (ORCID: https://orcid.org/0000-0002-2794-9449)
- Yu Fu (ORCID: https://orcid.org/0000-0002-1203-6970)
- Yanjun Jin
- Hang Zhao (ORCID: https://orcid.org/0000-0002-9531-7574)
- Chun Yang (ORCID: https://orcid.org/0000-0003-1540-4385)
- Yong Gu (ORCID: https://orcid.org/0000-0002-8818-9121)
- Yang Chen (ORCID: https://orcid.org/0000-0002-2400-8205)
- Mei Zhang (ORCID: https://orcid.org/0000-0003-0227-4323)
- Shuang Li (ORCID: https://orcid.org/0000-0002-6344-8377)
- Tao Yang (ORCID: https://orcid.org/0000-0001-6375-3622)
- Xianyong Yin
Institutions
- Nanjing Medical University (CN)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1210/clinem/dgaf303
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35