Characterization of extracellular vesicle-associated DNA and proteins derived from organotropic metastatic breast cancer cells
Taken together, the characterization of EV cargo in a unique model of BC organotropism demonstrated that EV-DNA and EV proteomes were informative of normal and cancer states. This work could help to identify BC biomarkers associated with site-specific metastasis and new therapeutic targets.
Authors
- Lorne Taylor
- Julia V. Burnier (ORCID: https://orcid.org/0000-0002-2184-2157)
- Noélie Douanne
- Mohamed Abdouh (ORCID: https://orcid.org/0000-0003-0702-9335)
- Thupten Tsering (ORCID: https://orcid.org/0000-0002-4613-5790)
- Kyle Dickinson (ORCID: https://orcid.org/0000-0002-2245-8640)
- Amélie Nadeau (ORCID: https://orcid.org/0009-0009-7074-0112)
- Jenna Cleyle (ORCID: https://orcid.org/0000-0001-6691-9966)
- Peter M. Siegel (ORCID: https://orcid.org/0000-0002-5568-6586)
- Laura Kienzle
Institutions
- McGill University Health Centre (CA)
- McGill University (CA)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1186/s13046-025-03418-3
- Citations
- 4
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- McGill University
- McGill University Health Centre
- University of Leeds
- Fonds de Recherche du Québec - Santé