Ergotamine enhances circadian amplitude and diurnally mitigates nitroglycerin-induced mechanical hypersensitivity
Ergotamine has substantial circadian rhythm modification effects in both cellular and animal models. Ergotamine's circadian effects appear to be mediated through serotonin 1D and 2C receptors, providing a rationale for why sub-psychedelic doses of psilocybin (which induces psychedelic responses through the serotonin 2A receptor) might be effective. Ergotamine's peak effect on hindpaw thresholds at ZT4 suggests that ergotamine may be more effective at certain times of day.
Authors
- Hwayoung Baek
- Emma Freeman
- Chorong Han
- Seung‐Hee Yoo (ORCID: https://orcid.org/0000-0002-9930-560X)
- Mark J. Burish (ORCID: https://orcid.org/0000-0002-8931-6436)
- Celia K. Tran (ORCID: https://orcid.org/0000-0002-4034-4727)
- Zheng Chen (ORCID: https://orcid.org/0000-0002-2464-5474)
- Eunju Kim (ORCID: https://orcid.org/0000-0003-2235-470X)
- Ji Ye Lim
Institutions
- Kongju National University (KR)
- The University of Texas Health Science Center (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1186/s10194-025-02008-0
- Citations
- 5
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 4.57
Funders
- Welch Foundation
- National Institutes of Health
- National Institute on Aging
- National Institute of General Medical Sciences
- National Institute of Neurological Disorders and Stroke