A non-inferiority randomised controlled trial of a shorter acetylcysteine regimen for paracetamol overdose – the SARPO trial
We aimed to examine a simple and shorter strategy for the antidotal administration of acetylcysteine in patients with low-risk paracetamol overdose. The new shortened protocol of 12 hours duration is safe and effective, and applicable to about one-third of acute paracetamol overdoses. The findings will make acetylcysteine treatment easier for treating physicians, with a shortened length of stay. The protocol cannot be extended to high-risk paracetamol overdoses, including massive and staggered ingestions, without further study.
Authors
- Michael A. Downes (ORCID: https://orcid.org/0000-0003-3608-144X)
- Geoffrey K. Isbister (ORCID: https://orcid.org/0000-0003-1519-7419)
- Ingrid Berling (ORCID: https://orcid.org/0000-0002-8993-2693)
- Nicholas A. Buckley (ORCID: https://orcid.org/0000-0002-6326-4711)
- Angela L. Chiew (ORCID: https://orcid.org/0000-0002-0079-5056)
- Katherine Isoardi (ORCID: https://orcid.org/0000-0002-1176-7923)
- Colin B. Page (ORCID: https://orcid.org/0000-0002-6924-8130)
- Keith Harris (ORCID: https://orcid.org/0000-0003-0724-1088)
Institutions
- Princess Alexandra Hospital (AU)
- Prince of Wales Hospital (AU)
- Calvary Mater Newcastle Hospital (AU)
- University of Newcastle Australia (AU)
Publication Details
- Journal
- Journal of Hepatology
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1016/j.jhep.2025.05.008
- Citations
- 4
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 6.23
Funders
- Emergency Medicine Foundation
- National Health and Medical Research Council