Methylation testing versus cervical cytology for triage of HPV-positive women: A comparative study
The GynTect six-gene methylation test provides higher diagnostic accuracy than cervical cytology in the triage of HPV-positive women. Its superior sensitivity and specificity make it a valuable tool for improving risk stratification in HPV-based cervical cancer screening. These findings support the integration of methylation-based testing into screening programs to enhance diagnostic precision and optimize patient management.
Authors
- M.X Wang
- Yurong Fu (ORCID: https://orcid.org/0000-0003-3548-7894)
- Qingzhi Zhai (ORCID: https://orcid.org/0000-0002-7328-2948)
- Nina Zhang (ORCID: https://orcid.org/0000-0002-6857-1091)
- Fuli Li (ORCID: https://orcid.org/0000-0003-0381-2234)
- Ying Ma (ORCID: https://orcid.org/0000-0003-3282-4410)
- Lian Li (ORCID: https://orcid.org/0000-0001-8628-4101)
Institutions
- Chinese PLA General Hospital (CN)
- Beijing Haidian Hospital (CN)
Publication Details
- Journal
- Diagnostic Microbiology and Infectious Disease
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1016/j.diagmicrobio.2025.116917
- Citations
- 5
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 6.77
Funders
- General Logistics Department, People's Liberation Army
- Central Military Commission