Isoliquiritigenin attenuated cognitive impairment, cerebral tau phosphorylation and oxidative stress in a streptozotocin-induced mouse model of Alzheimer's disease
In conclusion, our findings suggest that isoliquiritigenin ameliorates streptozotocin-induced cognitive impairment, hyperphosphorylated tau, oxidative stress, mitochondrial dysfunction and synaptic impairment by decreasing mTOR and ERK activity and increasing GSK-3β activity.
Authors
- Yan Xiao (ORCID: https://orcid.org/0000-0003-4242-6387)
- Yuanshang Wang (ORCID: https://orcid.org/0009-0006-7213-1669)
- Xiaolan Qi (ORCID: https://orcid.org/0000-0002-9108-6772)
- Yuanting Ding
- Zhi Tang (ORCID: https://orcid.org/0000-0002-1670-9183)
- Ruiqing Ni
- Tongtong Sha
Institutions
- Guiyang Medical University (CN)
- University Hospital of Bern (CH)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1016/j.lfs.2025.123759
- Citations
- 5
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 7.79