Immune-aging at diagnosis determines T-cell recovery in childhood leukemia survivors
We show that T cells in survivors of childhood leukemia exhibit distinct profiles dominated by aging-associated changes and consistent with premature immune aging. Immune profiles during survivorship in biospecimens (n = 251) from uniformly-treated children with B-acute lymphoblastic leukemia recapitulate heterogeneity at diagnosis in individual patients and correlate with genetic-risk subtypes. These data suggest that pre-therapy immune aging may determine variance in immune status during survivorship.
Authors
- Taylor Lawrence
- Sharon M. Castellino (ORCID: https://orcid.org/0000-0001-8367-2002)
- Shivani Kapadia (ORCID: https://orcid.org/0000-0002-1683-4742)
- Kavita M. Dhodapkar (ORCID: https://orcid.org/0000-0003-0587-4172)
- Ava Horvat
- Maryam I. Azeem (ORCID: https://orcid.org/0000-0002-4369-5637)
- Deborah DeRyckere (ORCID: https://orcid.org/0000-0002-7457-9006)
- Madhav V. Dhodapkar (ORCID: https://orcid.org/0000-0002-8249-5988)
Institutions
- Emory University (US)
- Fred Hutch Cancer Center (US)
- Aflac (United States) (US)
- Children's Healthcare of Atlanta (US)
Publication Details
- Journal
- npj Aging
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1038/s41514-025-00233-0
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Leukemia and Lymphoma Society
- Children's Healthcare of Atlanta
- National Institutes of Health