IFI204 in microglia mediates traumatic brain injury-induced mitochondrial dysfunction and pyroptosis via SENP7 interaction
The interaction between IFI204 and SENP7 promotes microglial pyroptosis and related mitochondrial dysfunction. Furthermore, in the case of TBI, we hypothesize that targeting IFI204 might yield therapeutic benefits.
Authors
- Ting Guo (ORCID: https://orcid.org/0000-0002-6700-0967)
- Peiqiang Lin
- Fan Lin (ORCID: https://orcid.org/0000-0001-9169-9416)
- Chunjin Lin (ORCID: https://orcid.org/0000-0002-0109-1464)
- Mouwei Zheng
- Jianhao Chen (ORCID: https://orcid.org/0009-0006-4363-0549)
- Xinyu Zhou (ORCID: https://orcid.org/0000-0002-0178-1406)
- Yongxing Lai
Institutions
- Fujian Medical University (CN)
- The First People’s Hospital of Lianyungang (CN)
- Fujian Provincial Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Kangda College of Nanjing Medical University
- Nanjing Medical University (CN)
Publication Details
- Journal
- Cell Biology and Toxicology
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1007/s10565-025-10032-8
- Citations
- 4
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Natural Science Foundation of Fujian Province