Bidirectional modulation of Alzheimer’s disease via gut microbiota: rescue by fecal transplantation from healthy donors and aggravation by colitis-associated dysbiosis
Our findings demonstrate that gut microbiota composition bidirectionally influences AD progression, with FMT from healthy donors attenuating neuroinflammation and pathology, while colitis-associated dysbiosis exacerbates disease hallmarks. Our study positions microbiota-targeted therapies as a promising strategy to modulate AD progression through the gut-brain axis.
Authors
- Huina Liu (ORCID: https://orcid.org/0000-0002-0722-7158)
- Chenglong Zhou
- Xin Feng (ORCID: https://orcid.org/0000-0002-1086-801X)
- Huadong Fan (ORCID: https://orcid.org/0000-0001-5282-4843)
- Yihong Li (ORCID: https://orcid.org/0000-0002-6746-3582)
- Ting Cai (ORCID: https://orcid.org/0000-0001-7614-0550)
Institutions
- Zhejiang Wanli University (CN)
- Ningbo No. 2 Hospital (CN)
- Ningbo Institute of Industrial Technology (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-05-23
- DOI
- https://doi.org/10.3389/fnins.2025.1593854
- Citations
- 5
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- Natural Science Foundation of Ningbo