The role of E2F1 in promoting EIF4EBP1 transcription in cryptorchid mice: association with autophagy in germ cells
E2F1 regulates EIF4EBP1 expression in cryptorchidism, contributing to excessive autophagy and apoptosis. Inhibiting E2F1 reduces these pathological processes, alleviating testicular damage and improving fertility, highlighting potential therapeutic targets for cryptorchidism.
Authors
- Xiangming Wu
- Xiao-Yun Wang (ORCID: https://orcid.org/0000-0002-5864-5827)
- Danxiong Sun (ORCID: https://orcid.org/0009-0002-5069-9713)
- Lin Yang (ORCID: https://orcid.org/0000-0003-4668-0083)
- Hailong Zhang (ORCID: https://orcid.org/0000-0002-3906-0890)
- Jianguo Zhang (ORCID: https://orcid.org/0000-0003-1983-8455)
- Lili Xiao (ORCID: https://orcid.org/0000-0003-0542-2723)
- Yanhui Liu
Institutions
- Inner Mongolia Maternal and Child Health (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-05-23
- DOI
- https://doi.org/10.3389/fgene.2025.1536672
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00