Co-detection of respiratory pathogens in children with Mycoplasma pneumoniae pneumonia: a multicenter study
Multi-pathogen co-infections substantially influence the severity of pediatric MPP. The findings highlight the diagnostic value of tNGS for identifying co-pathogens and underscore the predictive potential of inflammatory biomarkers (especially IL-6 and IL-10). The integration of tNGS and these biomarkers may facilitate early detection and targeted therapeutic interventions, thereby improving prevention and treatment outcomes in pediatric MPP.
Authors
- Danli Lu (ORCID: https://orcid.org/0000-0003-3667-1415)
- Hanmin Liu (ORCID: https://orcid.org/0000-0002-4633-911X)
- Yanhua Niu (ORCID: https://orcid.org/0000-0002-8093-908X)
- Run Guo
- Xiaoyan Dong (ORCID: https://orcid.org/0000-0002-8040-5897)
- Quan Lü (ORCID: https://orcid.org/0000-0002-6007-2677)
- Zihao Lin
- Li Li (ORCID: https://orcid.org/0000-0003-4802-8689)
- Xu Wang (ORCID: https://orcid.org/0000-0003-1094-1843)
- Rui Li (ORCID: https://orcid.org/0000-0002-5716-9259)
- Hailin Zhang (ORCID: https://orcid.org/0000-0001-8757-9905)
- Lina Chen (ORCID: https://orcid.org/0000-0001-9066-2099)
- Wenhao Yang (ORCID: https://orcid.org/0000-0003-4788-6446)
- Yingxue Zou
- Fangfang Lyu
- Haojie Wang (ORCID: https://orcid.org/0009-0002-3260-811X)
- Li Luo
Institutions
- Sichuan University (CN)
- Wenzhou Medical University (CN)
- West China Second University Hospital of Sichuan University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
- Yan'an University (CN)
- Tianjin Children's Hospital (CN)
- Shanghai Children's Hospital (CN)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-05-23
- DOI
- https://doi.org/10.3389/fped.2025.1482880
- Citations
- 8
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 10.83
Funders
- Tianjin Municipal Health Commission
- National Natural Science Foundation of China