Targeting the leptin receptor promotes MDA-MB-231 cells’ metabolic reprogramming and malignancy: the role of extracellular vesicles derived from obese adipose tissue
Overall, our results highlight how obese adipose tissue modulates breast cancer cell behavior, with leptin-enriched EVs playing a central role in driving migration, metabolic reprogramming, and invasiveness, thereby promoting tumor malignancy. This study underscores the importance of EVs in the obesity-cancer link and offers new insights for therapeutic strategies targeting leptin signaling and EV-mediated communication in breast cancer.
Authors
- Christina Barja‐Fidalgo (ORCID: https://orcid.org/0000-0002-1917-4401)
- Rangel Eduardo Santos (ORCID: https://orcid.org/0000-0002-0376-2241)
- João Alfredo Moraes (ORCID: https://orcid.org/0000-0002-8563-6432)
- Victor Aguiar Franco (ORCID: https://orcid.org/0009-0008-0169-264X)
- Isadora Ramos-Andrade (ORCID: https://orcid.org/0000-0002-6894-0379)
- Mariana Renovato‐Martins (ORCID: https://orcid.org/0000-0002-9860-5272)
- Carol Costa Encarnação
- Luiz Gabriel Xavier Botelho
- Luiz Guilherme Kraemer‐Aguiar (ORCID: https://orcid.org/0000-0002-3528-5881)
- Carolinne Souza Amorim (ORCID: https://orcid.org/0000-0002-2910-6285)
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- University of Miami (US)
- Universidade Federal Fluminense (BR)
- Universidade do Estado do Rio de Janeiro (BR)
- Hospital Universitário Pedro Ernesto (BR)
- Universidade Federal do Estado do Rio de Janeiro (BR)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-05-23
- DOI
- https://doi.org/10.3389/fonc.2025.1568524
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Universidade do Estado do Rio de Janeiro